El Dein Selim M S
Zentralbl Bakteriol Naturwiss. 1978;133(4):369-74. doi: 10.1016/s0323-6056(78)80055-x.
One strain of actinomycetes, designated as MYS-20 A, was isolated from the Egyptian soil. The organism produces a substance that appears to be different from previously described antibiotics. The substance was named "Aramycin". A description of the strain of actinomyces MYS 20 A is given as well as conditions of growth for maximum production of the antibiotic substance. The bacterial and fungal spectra of aramycin are given. The substance appears to exhibit a very significant cytotoxic effect. The antibiotic was toxic to mice, the lethal dose being, however, about 15 times higher than the curative dose.
从埃及土壤中分离出一种放线菌菌株,命名为MYS-20 A。该菌株产生一种似乎与先前描述的抗生素不同的物质。该物质被命名为“阿拉霉素”。文中给出了放线菌MYS 20 A菌株的描述以及抗生素物质最大产量的生长条件。还给出了阿拉霉素的细菌和真菌谱。该物质似乎具有非常显著的细胞毒性作用。这种抗生素对小鼠有毒,然而致死剂量约为治疗剂量的15倍。