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急性洋地黄中毒的预后因素(作者译)

[Prognostic factors in acute digitalis poisoning (author's transl)].

作者信息

Dally S, Alperovitch A, Lagier G, Bismuth C, Fournier E

出版信息

Nouv Presse Med. 1981 Jun 20;10(27):2257-60.

PMID:7267327
Abstract

The prognostic significance of various clinical and biochemical factors was investigated in 179 patients who had absorbed more than 2 mg of digitoxin. The mortality rate in this series was 17%. Supraventricular arrythmias had no influence on prognosis, but the death risk was higher in males and in patients with A-V block. It increased with age, with digitoxin and potassium serum levels and even more with persistent hyperkalemia. Two other factors, previous heart disease and vomiting, were also significant in patients without heart block. Calculated on the basis of 4 clinical factors, the mortality rate varied from 2 to 74%. The death risk in acute digitalis poisoning can therefore be easily assessed from simple clinical criteria.

摘要

对179例摄入超过2毫克地高辛的患者,研究了各种临床和生化因素的预后意义。该组患者的死亡率为17%。室上性心律失常对预后无影响,但男性及患有房室传导阻滞的患者死亡风险较高。死亡风险随年龄、地高辛和血清钾水平升高而增加,持续性高钾血症时死亡风险增加更明显。另外两个因素,即既往心脏病史和呕吐,在无心脏传导阻滞的患者中也具有显著意义。根据4项临床因素计算,死亡率在2%至74%之间。因此,急性洋地黄中毒的死亡风险可通过简单的临床标准轻松评估。

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