Palangié A, Lassau F, Moreau T, Noury-Duperrat G, Cottenot F
Nouv Presse Med. 1981 Jun 27;10(28):2337-41.
In a retrospective study of 95 patients seen between 1950 and 1978, the outcome of malignant melanoma levels III, IV and V of Clark's classification was reviewed. Patients with lentigo malignant melanoma were excluded. The overall survival rate was 63% at 5 years and 48% at 10 years. For the whole population of patients significant differences in survival rate were associated with level (p = 0,00002), thickness (less than 2 mm or greater than or equal to 2 mm; p less than 0.0,0001) and histological type (p = 0,02). The significance of prognostic variables taken separately was calculated by the Breslow method and was found to be: p = 0,0005 for thickness, p = 0,0009 for patient's age and p = 0,02 for histological type. In analysis with two variables, including level, thickness was the variable that added most to the information on prognosis supplied by level. For the population of patients with melanoma levels III and IV significant differences in survival rate were associated with thickness (less than 2 mm or greater than or equal to 2 mm; p less than 0,001), though not with level. When the variables were studied separately, thickness and patient's age were significant (p = 0,02 and p = 0,03 respectively). Analysis with two variables, including thickness, showed that age was the variable that added most to the information on prognosis supplied by thickness.
在一项针对1950年至1978年间就诊的95例患者的回顾性研究中，对克拉克分类法中III、IV和V级恶性黑色素瘤的预后进行了评估。排除了雀斑样痣恶性黑色素瘤患者。5年总生存率为63%，10年为48%。对于所有患者群体，生存率的显著差异与分级（p = 0.00002）、厚度（小于2mm或大于或等于2mm；p < 0.0001）和组织学类型（p = 0.02）有关。采用布雷斯洛方法计算了单独考虑的预后变量的显著性，结果发现：厚度的p值为0.0005，患者年龄的p值为0.0009，组织学类型的p值为0.02。在包含分级的双变量分析中，厚度是对分级所提供的预后信息增加最多的变量。对于III级和IV级黑色素瘤患者群体，生存率的显著差异与厚度（小于2mm或大于或等于2mm；p < 0.001）有关，而与分级无关。当分别研究这些变量时，厚度和患者年龄具有显著性（分别为p = 0.02和p = 0.03）。包含厚度的双变量分析表明，年龄是对厚度所提供的预后信息增加最多的变量。
