普尼拉明对心绞痛患者静息心电图QT间期的影响。
The effect of prenylamine on the QT interval of the resting electrocardiogram in patients with angina pectoris.
作者信息
Oakley D, Jennings K, Puritz R, Krikler D, Chamberlain D
出版信息
Postgrad Med J. 1980 Nov;56(661):753-6. doi: 10.1136/pgmj.56.661.753.
Abstract
Resting ECGs were recorded in 29 patients with angina pectoris before, during and after treatment with prenylamine 180 mg daily. The QT interval became significantly prolonged after one week of treatment. The prolongation persisted as long as therapy was continued, which was up to 6 months. After withdrawal of treatment the QT interval returned to normal within 2 weeks. In this study no serious problems were encountered by those patients in whom the QT interval was prolonged.
摘要
对29例心绞痛患者在每日服用180毫克普尼拉明治疗前、治疗期间和治疗后进行了静息心电图记录。治疗一周后QT间期显著延长。只要继续治疗，这种延长就会持续，最长可达6个月。停药后2周内QT间期恢复正常。在本研究中，QT间期延长的患者未出现严重问题。
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2
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Br Heart J. 1974 Oct;36(10):1001-4. doi: 10.1136/hrt.36.10.1001.
3
[Syncope by volley of ventricular spikes induced or encouraged by prenylamine].
Arch Mal Coeur Vaiss. 1973 Nov;66(11):1427-34.
4
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Am J Cardiol. 1978 Dec;42(6):1049-53. doi: 10.1016/0002-9149(78)90694-x.
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[Adverse effects of drugs: syncope due to prenylamine (author's transl)].
G Ital Cardiol. 1976;6(3):547-9.
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