Maffla A G
Pharmatherapeutica. 1981;2(9):601-6.
A double-blind, crossover trial was carried out in 26 children with psychiatric disorders to assess the effectiveness of treatment with minaprine (100 mg per day) or placebo, each treatment being given in random order for 4 weeks. Patients were assessed before treatment and at 14 day intervals using a modified 34-item Hamilton rating scale. The results showed a definite therapeutic superiority of minaprine over placebo and a good response was achieved in over 50% of the children, including those showing signs of the "hyperactive syndrome'. Minaprine was well tolerated by all the patients.
对26名患有精神疾病的儿童进行了一项双盲交叉试验，以评估米那普明（每日100毫克）或安慰剂治疗的有效性，每种治疗均以随机顺序给药4周。在治疗前及每隔14天，使用改良的34项汉密尔顿评定量表对患者进行评估。结果显示，米那普明在治疗上明显优于安慰剂，超过50%的儿童，包括那些有“多动综合征”迹象的儿童，都取得了良好的疗效。所有患者对米那普明耐受性良好。
