Pinelli A, Colombo R, Manitto P, Monti D
Pharmacology. 1981;22(6):337-42. doi: 10.1159/000137513.
Allylisopropylacetamide (AIA), a drug known to cause lesions in porphyrin and lipid metabolism, and drugs with structure related to AIA [propylisopropylacetamide (PIA) and 2-isopropyl-4-hydroxyvaleric acid] were injected subcutaneously into rats. Measurements were taken of the effect of these compounds on the levels of 5-aminolevulinic acid synthetase (ALA synthetase) and hepatic porphyrins and on the values of hepatic and plasmatic triglycerides and plasma free fatty acids. To a different degree, both AIA and PIA increase the activity of ALA synthetase, and also increase the levels of hepatic porphyrins and hepatic and plasmatic triglycerides, while they both initially lower the levels of plasmatic free fatty acids (FFAs). The administration of 2-isopropyl-4-hydroxyvaleric acid has no effect on the parameters studied. The findings seem to suggest that the activity affecting porphyrin and lipid metabolism is connected in both cases with the presence of the amide function.
烯丙基异丙基乙酰胺（AIA）是一种已知会导致卟啉和脂质代谢出现病变的药物，将与AIA结构相关的药物[丙基异丙基乙酰胺（PIA）和2-异丙基-4-羟基戊酸]皮下注射到大鼠体内。测定了这些化合物对5-氨基乙酰丙酸合成酶（ALA合成酶）水平、肝脏卟啉水平、肝脏和血浆甘油三酯值以及血浆游离脂肪酸的影响。AIA和PIA均不同程度地增加了ALA合成酶的活性，同时还提高了肝脏卟啉水平以及肝脏和血浆甘油三酯水平，而它们最初都会降低血浆游离脂肪酸（FFA）水平。给予2-异丙基-4-羟基戊酸对所研究的参数没有影响。这些发现似乎表明，在这两种情况下，影响卟啉和脂质代谢的活性都与酰胺官能团的存在有关。
