Pavlovskaia N I, Matveeva T S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(12):1776-83.
Studies on the cortex of rats during different periods following ligation of the carotid arteries demonstrated an early appearance of ischemic changes, which were characterized by different states of the nervous cells, glial elements and capillaries. The largest group consisted of neurons of the deep cortical layers, which showed reactive states of the nucleus and nucleoli, as well as signs of chromatolysis in the cytoplasma. Less distributed form of pathology involved changes of the "dark" type, involving small stellite and pyramidal neurons of the upper cortical layer. Changes of the glial elements may be mainly considered as signs of oedema and partial melting. These changes demonstrate not only a different sensibility of neurons of the upper and lower cortical layers, but different mechanisms of the structural regulation in the cell metabolism, providing its optimal level and organization for each functional state.
对大鼠颈动脉结扎后不同时期的皮质进行的研究表明，缺血性变化出现较早，其特征为神经细胞、神经胶质成分和毛细血管呈现不同状态。最大的一组是深层皮质层的神经元，它们表现出细胞核和核仁的反应性状态，以及细胞质中的染色质溶解迹象。较少见的病理分布形式是“深色”类型的变化，涉及上层皮质层的小型卫星神经元和锥体神经元。神经胶质成分的变化主要可视为水肿和部分溶解的迹象。这些变化不仅表明上层和下层皮质层神经元的敏感性不同，还表明细胞代谢中结构调节的不同机制，为每种功能状态提供其最佳水平和组织。
