Ferle-Vidović A, Petrović D, Vidić Z, Osmak M, Kadija K
Radiat Environ Biophys. 1981;19(3):197-203. doi: 10.1007/BF01324187.
A series of experiments has been undertaken in order to test the biological properties of neutrons produced in the cyclotron of the Institute "Ruder Bosković" (IRB) in Zagreb. Protective effect of AET (2-amino ethylisothiuronium bromide hydrobromide) on survival of L cells irradiated by fast neutrons generated in the IRB cyclotron were studied by employing the single cell clonal growth method. For comparison the protective effect of AET after gamma irradiation has also been studied. The most important findings that have emerged from these experiments can be summarized as follows: (1) Protective effect of AET was present after gamma irradiation only. (2) The degree of protection was dependent on AET concentration in the growth medium. (3) No protective effect was found after neutron irradiation. These findings are in agreement with the generally less efficient protection of this compounds after high-LET irradiation.
为了测试萨格勒布“鲁德·博斯科维奇研究所”（IRB）回旋加速器产生的中子的生物学特性，已经进行了一系列实验。采用单细胞克隆生长法研究了AET（氢溴酸2-氨基乙异硫脲）对IRB回旋加速器产生的快中子辐照的L细胞存活的保护作用。为作比较，还研究了γ射线辐照后AET的保护作用。这些实验得出的最重要的发现可总结如下：（1）仅在γ射线辐照后存在AET的保护作用。（2）保护程度取决于生长培养基中AET的浓度。（3）中子辐照后未发现保护作用。这些发现与该化合物在高传能线密度辐照后通常保护效率较低的情况一致。
