胃泌素：大鼠餐后胃组胺动员过程中的必需中间产物。

Gastrin: obligatory intermediate in the postprandial mobilization of gastric histamine in the rat.

作者信息

Håkanson R, Hedenbro J, Liedberg G, El Munshid H A, Rehfeld J F

出版信息

Experientia. 1977 Nov 15;33(11):1541-3. doi: 10.1007/BF01918860.

DOI:10.1007/BF01918860

Abstract

In unoperated fasted rats, feeding raised the serum gastrin concentration, reduced the gastric mucosal histamine content and activated the gastric histidine decarboxylase. The reduction of gastric histamine and activation of histidine decarboxylase was induced also by the injection of pentagastrin. In antrectomized rats, feeding failed to produce these effects. Injection of pentagastrin, however, still lowered gastric histamine and activated gastric histidine decarboxylase. Thus, antral gastrin seems to be an obligatory mediator of the postprandial activation of histidine decarboxylase and mobilization of histamine.

摘要

在未手术的禁食大鼠中，进食可提高血清胃泌素浓度，降低胃黏膜组胺含量并激活胃组织胺脱羧酶。注射五肽胃泌素也可诱导胃组胺减少和组胺脱羧酶激活。在胃窦切除的大鼠中，进食未能产生这些效应。然而，注射五肽胃泌素仍可降低胃组胺并激活胃组胺脱羧酶。因此，胃窦胃泌素似乎是餐后组胺脱羧酶激活和组胺动员的必要介质。