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[儿童瓣膜置换术:171例手术患者的结果及长期随访]

[Valve replacement in children: results and long-term follow-up in 171 operated patients].

作者信息

Friedli B, Friedli G M, Ben Ismail M, Rouge J C, Hahn C, Faidutti B

出版信息

Schweiz Med Wochenschr. 1981 Jul 7;111(27-28):1044-8.

PMID:7268359
Abstract

171 children aged 2-17 years underwent cardiac valve replacement between 1969 and December 1979. Valve lesions were of rheumatic origin in 160 and congenital in 11 cases. Single valve replacement of the mitral valve was performed in 116 cases, of the aortic valve in 18 cases and of the tricuspid valve once. Double valve replacement was done in 33 and triple valve replacement in 2 cases. Starr Edwards prostheses were used in most instances. Operative mortality was 5.9% and late death occurred in 8.7%. The follow-up period ranged from 1-9 years with a mean of 3.6 years. The majority of children have returned to a normal lifestyle and are symptom-free. Only 10% remain digitalized. As in adults, the most frequent complications were thromboembolic. 14 children (11%) had either an embolus or a valve thrombosis with a frequently of 3 per hundred patient-years. Other complications such as endocarditis or paravalvular leak were infrequent, and in most cases treatment was successful. Because of the markedly dilated hearts before operation it was possible in most children to use an adult size prosthesis, especially in the mitral position. Only a few children below 5 years of age received small mitral valve prostheses; they may need to be replaced ultimately by larger ones. Introduction of an embolus-free valve prosthesis for children would be a major advance. Unfortunately, porcine xenografts with their low embolic risk are not suitable for children as they often undergo rapid calcification.

摘要

1969年至1979年12月期间,171名2至17岁的儿童接受了心脏瓣膜置换术。瓣膜病变160例源于风湿性,11例源于先天性。116例行二尖瓣单瓣膜置换术,18例行主动脉瓣单瓣膜置换术,1例行三尖瓣单瓣膜置换术。33例行双瓣膜置换术,2例行三瓣膜置换术。大多数情况下使用的是斯塔尔·爱德华兹人工瓣膜。手术死亡率为5.9%,晚期死亡率为8.7%。随访时间为1至9年,平均3.6年。大多数儿童已恢复正常生活方式,且无症状。仅10%仍需使用洋地黄制剂。与成人一样,最常见的并发症是血栓栓塞。14名儿童(11%)发生了栓塞或瓣膜血栓形成,发生率为每100患者年3例。心内膜炎或瓣周漏等其他并发症较少见,且大多数情况下治疗成功。由于术前心脏明显扩大,大多数儿童有可能使用成人尺寸的人工瓣膜,尤其是二尖瓣位。仅少数5岁以下儿童使用了小型二尖瓣人工瓣膜;最终可能需要更换为更大尺寸的瓣膜。为儿童引入无栓塞风险的人工瓣膜将是一项重大进展。不幸的是,猪异种移植物虽然栓塞风险低,但由于其常迅速钙化,不适合儿童使用。

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