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兔实验性葡萄膜炎中睫状体和虹膜的扫描电镜研究

The ciliary body and the iris in experimental uveitis in rabbits. A scanning electron microscopic study.

作者信息

Davanger M, Pedersen O O

出版信息

Acta Ophthalmol (Copenh). 1978 Dec;56(6):857-64. doi: 10.1111/j.1755-3768.1978.tb03806.x.

DOI:10.1111/j.1755-3768.1978.tb03806.x
PMID:726884
Abstract

Acute anterior immunogenic uveitis of varying degree was induced in rabbits by the injection of human serum albumin into the vitreous body. After fixation and drying by the critical point method, the lens, the zonules, the vitreous and, in some specimens, coagulated exudate were removed by careful dissection. The surface of the ciliary body and the posterior surface of the iris were examined by scanning electron microscopy. In moderate uveitis, the ciliary body was covered by a thin layer of leucocytes enmeshed in fibrin strands. Scattered deposits of fibrin and a few leucocytes were also found in the iris. In severe uveitis, the processes of the ciliary body had nearly disappeared because of oedema and exudate, which also contained erythrocytes. The numerous leucocytes had marked excrescences formed by folds of the cell membrane. Fibrin seemed to play a role in the attachment of the leucocytes on the surface of the ciliary body.

摘要

通过向兔玻璃体注射人血清白蛋白,诱发不同程度的急性前免疫性葡萄膜炎。经临界点法固定和干燥后,小心解剖去除晶状体、悬韧带、玻璃体,部分标本中的凝固渗出物也一并去除。通过扫描电子显微镜检查睫状体表面和虹膜后表面。在中度葡萄膜炎中,睫状体被一层包埋在纤维蛋白丝中的薄白细胞层覆盖。虹膜中也发现了散在的纤维蛋白沉积物和少量白细胞。在重度葡萄膜炎中,睫状体的突起因水肿和渗出物(其中也含有红细胞)几乎消失。大量白细胞有由细胞膜褶皱形成的明显赘生物。纤维蛋白似乎在白细胞附着于睫状体表面的过程中起作用。

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J Ophthalmic Inflamm Infect. 2015 Apr 2;5:10. doi: 10.1186/s12348-015-0036-1. eCollection 2015.
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Immunological concepts and the eye: a review of the classical and ocular arthus reactions.
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