在氨基氧乙酸存在的情况下大鼠肾线粒体中谷氨酰胺的代谢
Metabolism of glutamine in rat kidney mitochondria in the presence of aminooxyacetate.
作者信息
Strzelecki T, Olejnik B, Rogulski J
出版信息
Acta Biochim Pol. 1980;27(3-4):265-72.
PMID:7269972
Abstract
- Aminooxyacetate has no effect on respiration of rat kidney cortex mitochondria in the presence of glutamine but it inhibits respiration in the presence of glutamate to the values of endogenous respiration. 2. Rat kidney mitochondria in state 3 produce aspartate from glutamine in the amount corresponding to almost 50% of the glutamate formed intramitochondrially. 3. Aminooxyacetate affects neither formation of ammonia nor of aspartate from glutamine but it inhibits aspartate synthesis in the mitochondria treated with Triton X-100.
摘要
- 在谷氨酰胺存在的情况下，氨氧基乙酸对大鼠肾皮质线粒体的呼吸作用没有影响，但在谷氨酸存在时，它会将呼吸作用抑制至内源性呼吸的值。2. 处于状态3的大鼠肾线粒体从谷氨酰胺产生天冬氨酸的量几乎相当于线粒体内形成的谷氨酸的50%。3. 氨氧基乙酸既不影响谷氨酰胺产生氨也不影响其产生天冬氨酸，但它会抑制用 Triton X - 100处理的线粒体中的天冬氨酸合成。
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