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[间断性出血对麻醉兔血浆及脑脊液中血管加压素浓度的影响]

[Effect of discontinuous hemorrhage on plasma and cerebrospinal fluid vasopressin concentration in anesthesized rabbits].

作者信息

Schuart J, Schellenberg R, Blume M

出版信息

Acta Biol Med Ger. 1981;40(2):201-7.

PMID:7269990
Abstract

Repeated withdrawal of 15 ml arterial blood at 10 min intervals produced marked hypovolaemia and hypotension with plasma vasopressin concentration increasing exponentially from 53 microE/ml to more than 700 microE/ml contrary to the hypovolaemia. After the first blood withdrawal there exists a linear correlation between the increase of the plasma vasopressin concentration and the decrease of the mean arterial blood pressure. With 61.5 microE/ml the cerebrospinal fluid withdrawn following the last bleeding likewise showed a very high vasopressin level. After extraction of the hormone from plasma and cerebrospinal fluid the vasopressin concentration was determined by means of the antidiuretic bioassay in the water-loaded rat.

摘要

每隔10分钟重复抽取15毫升动脉血会导致明显的血容量过低和低血压,此时血浆血管加压素浓度呈指数级增长,从53微国际单位/毫升升至700微国际单位/毫升以上,这与血容量过低的情况相反。首次采血后,血浆血管加压素浓度的升高与平均动脉血压的降低之间存在线性关系。最后一次出血后抽取的脑脊液中血管加压素水平同样非常高,为61.5微国际单位/毫升。从血浆和脑脊液中提取激素后,通过对水负荷大鼠进行抗利尿生物测定来确定血管加压素浓度。

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