Sørensen P S, Gjerris F, Hammer M
Ann Neurol. 1984 May;15(5):435-40. doi: 10.1002/ana.410150506.
Cerebrospinal fluid and plasma vasopressin were measured in patients with cerebral disorders associated with varying levels of elevated intracranial pressure. The mean cerebrospinal fluid vasopressin concentration was significantly increased in patients with pseudotumor cerebri (2.0 +/- 0.2 [SEM] pg/ml), intracranial tumor (2.3 +/- 0.4 pg/ml), and intracranial hemorrhage (1.9 +/- 0.3 pg/ml) compared with control patients (1.2 +/- 0.1 pg/ml). A significant relationship was found between intracranial pressure and the cerebrospinal fluid vasopressin concentration within all groups of patients and in the whole sample as well (r = 0.79; p less than 0.001). In the groups of patients with intracranial tumor, hydrocephalus, and intracranial hemorrhage, some individuals showed plasma vasopressin concentrations inappropriate to the corresponding plasma osmolality, but no relationship was found between intracranial pressure and plasma vasopressin concentration. It is suggested that increased intracranial pressure is a stimulus to centrally released vasopressin. The clinical importance of increased cerebrospinal fluid vasopressin concentrations is still not known.
对患有与不同程度颅内压升高相关的脑部疾病的患者，测定了脑脊液和血浆中的血管加压素。与对照组患者（1.2±0.1[标准误]pg/ml）相比，假性脑瘤患者（2.0±0.2[标准误]pg/ml）、颅内肿瘤患者（2.3±0.4 pg/ml）和颅内出血患者（1.9±0.3 pg/ml）的脑脊液血管加压素平均浓度显著升高。在所有患者组以及整个样本中，均发现颅内压与脑脊液血管加压素浓度之间存在显著关系（r = 0.79；p<0.001）。在颅内肿瘤、脑积水和颅内出血患者组中，一些个体的血浆血管加压素浓度与相应的血浆渗透压不相称，但未发现颅内压与血浆血管加压素浓度之间存在关系。提示颅内压升高是中枢释放血管加压素的刺激因素。脑脊液血管加压素浓度升高的临床意义仍不清楚。
