Takubo K
Acta Pathol Jpn. 1981 May;31(3):349-59. doi: 10.1111/j.1440-1827.1981.tb01379.x.
The entire mucosa of the esophagogastric junction zone (E.G.J.) was examined histologically in 63 cases of total gastrectomy and 47 cases of esophageal resection. The squamocolumnar junction in E.G.J. was classified into three types, 1. Clear-cut demarcation type was found in 21 (19%) out of the total 110 cases, 2. Subepithelial inclusions of ectopic gastric epithelium type in 81 (74%) out of 110 cases, and 3. Barrett esophagus type in 8 (7%) out of 110 cases. By the primary disease, 4 out of 8 cases of type 3 were found in the cases of esophageal ulcer, and 4 were present in the cases of esophageal cancer. The mucosa of E.G.J. showed a squamous metaplasia with reserve cell hyperplasia as in the cervix uteri. The reserve cell hyperplasia was observed in 26(24%) out of 110 cases, and there were two cases which showed atypical change and nodular proliferation. The reserve cell hyperplasia and its atypical change were considered to be one of the sites for the development of squamous cell carcinoma in the junction zone. It was suggested that the primary site of squamous cell carcinoma in E.G.J. was not limited to the esophageal flat stratified squamous epithelium.
对63例全胃切除术和47例食管切除术患者的食管胃交界区（E.G.J.）的整个黏膜进行了组织学检查。E.G.J.的鳞柱状交界分为三种类型：1. 在110例中的21例（19%）发现为清晰分界型；2. 在110例中的81例（74%）为异位胃上皮的上皮下包涵体型；3. 在110例中的8例（7%）为巴雷特食管型。按原发疾病分类，3型的8例中有4例见于食管溃疡患者，4例见于食管癌患者。E.G.J.的黏膜表现为鳞状化生伴储备细胞增生，如同子宫颈。在110例中有26例（24%）观察到储备细胞增生，有2例表现为非典型改变和结节状增生。储备细胞增生及其非典型改变被认为是交界区鳞状细胞癌发生的部位之一。提示E.G.J.鳞状细胞癌的原发部位不限于食管扁平复层鳞状上皮。
