Autio-Harmainen H
Acta Pathol Microbiol Scand A. 1981 Mar;89(2):173-8. doi: 10.1111/j.1699-0463.1981.tb00205.x.
A qualitative light microscopic study was performed on 9 fetal congenital nephrotic (CNF) and 13 control placentas obtained from legal pregnancy terminations or spontaneous abortions at 16-20 weeks of gestation. From this material 6 CNF cases and 6 age matched controls were selected for morphometric analysis. The total villous volume and the ramification pattern of the villi were similar in CNF and controls. A significant decrease in the villous vascularization was found in CNF. It is suggested that disturbed oxygen exchange due to poor development of the villous vessels causes a compensatory hyperplasia of the placenta at birth in CNF. Electron microscopic investigation was performed on three CNF and two control placentas. No changes typical of fetal CNF were found in the villous ultrastructure. The syncytial microvillous projections seemed to be more numerous and longer in CNF, otherwise the structure of the trophoblastic layer of the villi and the lining of the subtrophoblastic vessels were identical in CNF and controls.
对9例胎儿先天性肾病（CNF）胎盘和13例对照胎盘进行了定性光学显微镜研究，这些胎盘取自妊娠16 - 20周时合法终止妊娠或自然流产的标本。从这些材料中选取了6例CNF病例和6例年龄匹配的对照进行形态计量分析。CNF胎盘和对照胎盘的绒毛总体积及分支模式相似。但发现CNF胎盘的绒毛血管化显著减少。提示绒毛血管发育不良导致的氧交换障碍，使得CNF胎儿出生时胎盘发生代偿性增生。对3例CNF胎盘和2例对照胎盘进行了电子显微镜检查。在绒毛超微结构中未发现典型的胎儿CNF改变。CNF胎盘的合体微绒毛突起似乎更多、更长，除此之外，CNF胎盘和对照胎盘的绒毛滋养层结构及滋养层下血管内衬相同。
