Zaidman G W, Brown S I
Am J Ophthalmol. 1981 Aug;92(2):178-82. doi: 10.1016/0002-9394(81)90766-2.
We treated six patients who had recurrent episodes of nontuberculous phlyctenular keratoconjunctivitis and progressive corneal vascularization and scarring with oral tetracycline. This treatment resulted in rapid relief of symptoms and the apparent arrest of this disease. There have been no complications secondary to the use of tetracycline. To date, there has been only one recurrence in the patients treated with tetracycline which consisted of mild conjunctival hyperemia. We believe oral tetracycline is a safe and effective treatment for resistant and recurrent nontuberculous phlyctenular keratoconjunctivitis and an alternative to topical corticosteroid treatment in those patients suffering from corticosteroid-induced complications.
我们用口服四环素治疗了6例复发性非结核性泡性角结膜炎且伴有进行性角膜血管化和瘢痕形成的患者。这种治疗使症状迅速缓解，且该病明显得到控制。使用四环素未出现继发并发症。迄今为止，接受四环素治疗的患者仅1例复发，表现为轻度结膜充血。我们认为口服四环素是治疗耐药性和复发性非结核性泡性角结膜炎的一种安全有效的方法，对于那些因使用局部皮质类固醇激素而出现并发症的患者来说，是局部皮质类固醇激素治疗的一种替代方法。
