Silva P, Spokes K
Am J Physiol. 1981 Aug;241(2):F151-5. doi: 10.1152/ajprenal.1981.241.2.F151.
The extrarenal disposal of potassium was studied in nephrectomized and adrenalectomized rats by measuring the rise in serum potassium produced during an infusion of 3 meq KCl/kg over 90 min. Adrenalectomy alone did not alter the volume of distribution of infused potassium in nephrectomized animals. When nephrectomy and adrenalectomy were combined with either insulin deficiency produced by streptozotocin or chemical sympathectomy induced by injection of 6-hydroxydopamine, potassium tolerance was significantly impaired. Hyperkalemia produced in chemically sympathectomized animals by potassium infusion was minimized by simultaneous infusion of epinephrine, an effect blocked by the beta-antagonist propranolol but not by the alpha-blocker phenoxybenzamine. These results suggest that extra renal uptake of potassium, in addition to being influenced by insulin and circulating catecholamines, is modulated by peripheral sympathetic activity.
通过测量在90分钟内输注3毫当量氯化钾/千克期间血清钾的升高，研究了肾切除和肾上腺切除大鼠体内钾的肾外处置情况。单独肾上腺切除并未改变肾切除动物体内输注钾的分布容积。当肾切除和肾上腺切除与链脲佐菌素诱导的胰岛素缺乏或注射6-羟基多巴胺诱导的化学性交感神经切除相结合时，钾耐受性显著受损。通过同时输注肾上腺素可使化学性交感神经切除动物因输注钾而产生的高钾血症降至最低，β受体拮抗剂普萘洛尔可阻断这一效应，而α受体阻滞剂酚苄明则无此作用。这些结果表明，钾的肾外摄取除受胰岛素和循环儿茶酚胺影响外，还受外周交感神经活动的调节。
