Eiler H, Baber W, Lyke W A, Scholtens R
Am J Vet Res. 1981 Mar;42(3):498-502.
The immersion of freshly collected Ostertagia ostertagi adults into saline solution (NaCl, 0.9%; pH 1.0) resulted in 100% mortality of worms within a 10-minute period. At pH 7.0, mortality was 58% after 270 minutes. At pH 2.2, which approximates the usual abomasal pH, 100% mortality resulted within 60 minutes. In the stomach of rats injected with an extract of O ostertagi (from the abomasum of cattle), there were decreased total secretion of hydrogen ions and volume of secretion (P less than 0.05) and increased mean pH of gastric secretion (P less than 0.05). These effects were similar to those found in stomach of rats treated with cimetidine. Results indicated that the pH of the abomasum was detrimental to parasitic survival and that hypochlorhydria found during ostertagiosis may be mediated partially by a chemical released from the parasite.
将刚采集的奥斯特他线虫成虫浸入盐溶液（氯化钠，0.9%；pH 1.0）中，10分钟内虫体死亡率达100%。在pH 7.0时，270分钟后死亡率为58%。在接近皱胃通常pH值的pH 2.2时，60分钟内死亡率达100%。在注射了奥斯特他线虫提取物（来自牛皱胃）的大鼠胃中，氢离子总分泌量和分泌量减少（P<0.05），胃分泌平均pH值升高（P<0.05）。这些效应与用西咪替丁治疗的大鼠胃中发现的效应相似。结果表明，皱胃的pH值对寄生虫存活有害，且在奥斯特他线虫病期间发现的胃酸过少可能部分由寄生虫释放的一种化学物质介导。
