局部麻醉药对大鼠离体半膈等长收缩的影响。

The effects of local anaesthetics on the isometric contraction of the isolated hemidiaphragm of the rat.

作者信息

Prostran M, Varagić V M

出版信息

Arch Int Pharmacodyn Ther. 1981 Mar;250(1):30-9.

Abstract

Local anaesthetics (benzocaine, tetracacine, lidocaine, cocaine, procaine) were found to depress both Td and dT/dt max of the isometric contraction of the isolated hemidiaphragm of the rat during direct electrical stimulation. The same substances were found to antagonize the action of aminophylline on Td and dT/dt max of the isolated hemidiaphragm during direct stimulation. The effect of higher concentrations of aminophylline was even reversed by cocaine, procaine and lidocaine. Increasing of calcium concentrations did not reverse the antagonistic action of aminophylline on Td and dT/dt max of the isometric contraction of the isolated hemidiaphragm. It is suggested that a change in the muscle membrane is responsible for the observed action of local anaesthetics on Td and dT/dt max, as well as for their antagonistic action towards aminophylline.

摘要

研究发现，局部麻醉药（苯佐卡因、丁卡因、利多卡因、可卡因、普鲁卡因）在直接电刺激时，可抑制大鼠离体半膈肌等长收缩的Td和dT/dt max。还发现相同物质在直接刺激时可拮抗氨茶碱对离体半膈肌Td和dT/dt max的作用。可卡因、普鲁卡因和利多卡因甚至可逆转高浓度氨茶碱的作用。增加钙浓度并不能逆转氨茶碱对离体半膈肌等长收缩Td和dT/dt max的拮抗作用。提示肌膜变化是局部麻醉药对Td和dT/dt max产生上述作用以及它们对氨茶碱产生拮抗作用的原因。