Pearle D L, Williford D, Gillis R A
Am J Cardiol. 1978 Dec;42(6):960-4. doi: 10.1016/0002-9149(78)90682-3.
The ability of practolol and propranolol of prevent ventricular fibrillation in experimental anterior myocardial infarction was compared in dogs subjected to ligation of the left anterior descending and first septal coronary arteries. This procedure, which causes ventricular fibrillation in 90 percent of animals within 30 minutes, was performed in control dogs and in dogs pretreated with propranolol (0.5 mg/kg body weight) or with practolol (1.5 to 2.5 mg/kg). These doses produced nearly equivalent shifts in isoproterenol-induced chronotropic dose-response curves, indicating equivalent degrees of beta adrenergic blockade. In 21 dogs with confirmed ligation, cardiogenic shock did not develop. Six of seven control dogs died with ventricular fibrillation. Six of seven dogs pretreated with propranolol also had fibrillation, whereas only one of the seven dogs pretreated with practolol manifested ventricular fibrillation during the 45 minute postligation observation period. Practolol afforded significant protection compared with no treatment or treatment with propranolol (P less than 0.05).
在结扎左冠状动脉前降支和第一间隔支的犬中，比较了心得宁和普萘洛尔预防实验性前壁心肌梗死时室颤的能力。对对照组犬以及用普萘洛尔（0.5mg/kg体重）或心得宁（1.5至2.5mg/kg）预处理的犬进行该操作，此操作会使90%的动物在30分钟内发生室颤。这些剂量在异丙肾上腺素诱导的变时剂量反应曲线上产生了几乎等效的偏移，表明β肾上腺素能阻滞程度相当。在21只确认结扎的犬中，未发生心源性休克。7只对照犬中有6只死于室颤。7只普萘洛尔预处理犬中有6只也发生了室颤，而7只心得宁预处理犬中在结扎后45分钟观察期内只有1只出现室颤。与未治疗或用普萘洛尔治疗相比，心得宁提供了显著的保护作用（P<0.05）。
