Kropf D
Bibl Psychiatr. 1981(161):141-51.
Within the context of psychological research on the mechanism of lithium prophylaxis mainly three questions are to be raised and hopefully answered: a) Can psychic effects of lithium be demonstrated during the free interval of manic-depressive patients under long-term lithium medication? b) Supposed that such lithium-induced effects could be demonstrated during the free interval, do they possess any significance for the prophylactic effect? c) Supposed that such prophylactically significant effects exist, do they refer to typical properties of the premorbid personality in which subjects with affective psychoses differ from normal subjects? A double-blind study in 14 manic-depressive patients during the free interval showed effects of lithium on learning, free recall, experience of time, and visual perception. The direction of the effects, i.e, increase or decrease versus corresponding values obtained under placebo, seems to be determined by the individual personality.
在关于锂盐预防机制的心理学研究背景下，主要有三个问题需要提出并有望得到解答：a）在长期服用锂盐药物的躁郁症患者的缓解期，能否证明锂盐对心理有影响？b）假设在缓解期能证明这种由锂盐引起的影响，它们对预防效果有任何意义吗？c）假设存在这种具有预防意义的效果，它们是否涉及情感性精神病患者与正常受试者不同的病前人格的典型特征？一项针对14名躁郁症患者缓解期的双盲研究表明，锂盐对学习、自由回忆、时间体验和视觉感知有影响。这些影响的方向，即与服用安慰剂时获得的相应值相比是增加还是减少，似乎由个体人格决定。
