人和大鼠药物乙酰化的生态遗传学研究。
Ecogenetic studies of drug acetylation in man and rats.
作者信息
Dubbels R, Khoory R, Schloot W
出版信息
Acta Anthropogenet. 1981;5(2):111-8.
Great intraindividual variation of N-acetyltransferase activity was found in human beings. Between nutritional factors and human or rat liver N-acetyltransferase activity a correlation has been observed. The proportion of rapid acetylators in human population correlates to fish protein supply (p less than 0.01). Laboratory rats of different inbred and outbred strains displayed altered enzyme activities when they were fed with different "standard diets". Furthermore, N-acetyltransferase is inhibited by a lot of naturally occurring compounds. In rats N-acetyltransferase activity values are polymorphically distributed; acetylation activity seems to be controlled by a mechanism different from man.
在人类中发现了N - 乙酰转移酶活性存在巨大的个体内差异。已观察到营养因素与人类或大鼠肝脏N - 乙酰转移酶活性之间存在相关性。人群中快速乙酰化者的比例与鱼类蛋白质供应相关（p小于0.01）。当不同近交系和远交系的实验大鼠喂食不同的“标准饮食”时，它们的酶活性会发生改变。此外，N - 乙酰转移酶受到许多天然存在的化合物的抑制。在大鼠中，N - 乙酰转移酶活性值呈多态分布；乙酰化活性似乎受一种与人类不同的机制控制。
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