Levy S B, Lilley J J, Stone R A
Am J Med Sci. 1978 Jul-Aug;276(1):57-66. doi: 10.1097/00000441-197807000-00005.
Human hypertension has been related to abnormalities of autonomic blood pressure regulation. In order to characterize a possible defect, we have studied several aspects of reflex autonomic circulatory control in normal subjects, patients with primary hypertension, and two types of subjects with uremia and elevated blood pressure. Phenylephrine infusion (a measurement of baroreceptor response to high pressure stimulus) resulted in similar hemodynamic changes in all types of subjects. However, all groups of patients exhibited significantly different hemodynamic responses to amyl nitrite inhalation (an index of baroreceptor response to low pressure stimulus). These results suggest that patients with uremia and those with primary hypertension differ from each other and normal subjects regarding baroreceptor reflex function. Furthermore, one type of uremic patient may have a neurogenic component to their hypertension similar to experimental animals following surgical section of afferent baroreceptor nerves.
人类高血压与自主神经对血压调节的异常有关。为了描述可能存在的缺陷，我们研究了正常受试者、原发性高血压患者以及两种伴有尿毒症和血压升高的受试者的反射性自主循环控制的几个方面。去氧肾上腺素输注（压力感受器对高压刺激反应的一种测量方法）在所有类型的受试者中均导致相似的血流动力学变化。然而，所有患者组对亚硝酸异戊酯吸入（压力感受器对低压刺激反应的一个指标）均表现出显著不同的血流动力学反应。这些结果表明，尿毒症患者和原发性高血压患者在压力感受器反射功能方面彼此不同，且与正常受试者也不同。此外，一种类型的尿毒症患者其高血压可能具有神经源性成分，类似于实验动物在传入压力感受器神经手术切断后的情况。
