[磷脂酶A2在线粒体中的定位]
[Phospholipase A2 localization in mitochondria].
作者信息
Severina E P, Evtodienko Iu V
出版信息
Biokhimiia. 1981 Jul;46(7):1199-201.
PMID:7272349
Abstract
The activation of mitochondrial phospholipase A2 by Ca2+ and Sr2+ has been studied. It was shown that complete inactivation of the enzyme occurs after treatment of isolated mitochondria with ruthenium red, inhibitor of Ca transport across the inner mitochondrial membrane. It was concluded that phospholipase A2 is localized on the inner mitochondrial membrane and that its activity is stimulated by Ca2+ on the side of the mitochondrial matrix.
摘要
对钙离子（Ca2+）和锶离子（Sr2+）激活线粒体磷脂酶A2的过程进行了研究。结果表明，在用钌红（一种跨线粒体内膜钙转运的抑制剂）处理分离的线粒体后，该酶会完全失活。由此得出结论，磷脂酶A2定位于线粒体内膜，其活性受线粒体基质一侧的Ca2+刺激。
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