Gorczynski R J, Klitzman B, Duling B R
Am J Physiol. 1978 Nov;235(5):H494-504. doi: 10.1152/ajpheart.1978.235.5.H494.
Arterioles and capillaries in the hamster cremaster muscle were observed during electrical stimulation of striated muscle fibers in order to characterize the microcirculatory basis of functional hyperemia. When contraction was restricted to single muscle fibers, responses were variable and frequently transient. Stimulation of either small bundles of muscle fibers or the entire cremaster muscle resulted in reproducible responses typified by: 1) a latency period, 2) an early, often transient phase of dilation, and 3) a second, slower phase of dilation. The latency varied inversely with contraction frequency, and the magnitude of the dilation varied directly with contraction frequency over the range 1--8/s. With stimulation of single fibers and small groups of fibers, arteriolar vasodilation was highly localized to regions of the arterioles that were in close apposition to the stimulated fibers. The number of capillaries with red blood cell flow increased during contraction, and the increase was graded with contraction frequency. The changes observed suggest that the vascular response during functional hyperemia is a two-part process and that the control processes are influenced by contraction frequency.
在对仓鼠提睾肌的横纹肌纤维进行电刺激期间，观察其小动脉和毛细血管，以确定功能性充血的微循环基础。当收缩局限于单根肌纤维时，反应多变且常常是短暂的。刺激小束肌纤维或整个提睾肌会产生可重复的反应，其特点为：1）潜伏期；2）早期通常为短暂的扩张期；3）第二个较慢的扩张期。潜伏期与收缩频率呈反比，在1 - 8次/秒的范围内，扩张幅度与收缩频率呈正比。在刺激单根纤维和小群纤维时，小动脉血管舒张高度局限于与受刺激纤维紧密相邻的小动脉区域。收缩期间有红细胞流动的毛细血管数量增加，且增加程度与收缩频率分级相关。观察到的这些变化表明，功能性充血期间的血管反应是一个分为两个部分的过程，并且控制过程受收缩频率的影响。
