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Protected environment - prophylactic antibiotic program for malignant sarcomas: randomized trial during remission induction chemotherapy.

作者信息

Bodey G P, Rodriguez V, Murphy W K, Burgess A, Benjamin R S

出版信息

Cancer. 1981 May 15;47(10):2422-9. doi: 10.1002/1097-0142(19810515)47:10<2422::aid-cncr2820471017>3.0.co;2-y.

DOI:10.1002/1097-0142(19810515)47:10<2422::aid-cncr2820471017>3.0.co;2-y
PMID:7272896
Abstract

Fifty-one valuable patients with malignant sarcomas were randomly allocated to receive three courses of remission induction chemotherapy with cyclophosphamide, vincristine, Adriamycin, and dimethyl triazeno imidazole carboxamide (CYVADIC) on the protected environment-prophylactic antibiotic for the control group (P = 0.22). The response rates (complete plus partial) were 71% and 67%, respectively. The durations of response were similar for both groups of patients, but the PEPA patients survived substantially longer (median, 84 weeks vs. 58 weeks). The frequency of infection was significantly lower among the PEPA patients, and the doses of CYVADIC could be escalated more often among these patients. Dosage escalation was associated with a higher complete remission rate and lower fatality rate.

摘要

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Protected environment - prophylactic antibiotic program for malignant sarcomas: randomized trial during remission induction chemotherapy.
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