金属对诱变和DNA修复的影响。
Effect of metals on mutagenesis and DNA repair.
作者信息
Rossman T G
出版信息
Environ Health Perspect. 1981 Aug;40:189-95. doi: 10.1289/ehp.8140189.
Abstract
Unlike the situation with organic compounds, metals do not show a high correlation between carcinogenicity and mutagenicity. An agent may be mutagenic by causing misreplication of DNA due to alterations of the DNA template, decreased fidelity of DNA polymerase, or inhibition of the proofreading of DNA replication. In addition, bacteria have an inducible, error-prone DNA repair system (SOS repair) whose activity results in mutagenesis. In the best studied example of metal mutagenesis, chromate, there is little evidence for the involvement of the SOS system. Metals may act as comutagens by inhibiting the repair of damage to DNA caused by another agent. This has been demonstrated for arsenite. Comutagens would not be detected by standard screening methods.
摘要
与有机化合物的情况不同，金属在致癌性和致突变性之间并未表现出高度相关性。一种物质可能通过以下原因导致DNA错误复制而具有致突变性：DNA模板改变、DNA聚合酶保真度降低或DNA复制校对功能受到抑制。此外，细菌具有一种可诱导的、易出错的DNA修复系统（SOS修复），其活性会导致诱变。在对金属诱变研究得最为充分的例子——铬酸盐中，几乎没有证据表明SOS系统参与其中。金属可能通过抑制另一种物质对DNA造成的损伤修复而充当共诱变剂。亚砷酸盐已证实存在这种情况。标准筛选方法无法检测到共诱变剂。
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