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葡萄糖酸钙和氯化钙对人体心脏循环参数的影响(作者译)

[Effects of calcium gluconate and calcium chloride on cardiocirculatory parameters in man (author's transl)].

作者信息

Hempelmann G, Piepenbrock S, Frerk C, Schleussner E

出版信息

Anaesthesist. 1978 Nov;27(11):516-22.

PMID:727423
Abstract

In 44 patients with congenital or acquired heart disease, functional class II--IV NYHAC, the effects of calcium gluconate (10 ml 10%) and calcium chloride (10 ml 5.5%) on hemodynamics, inotropy and myocardial oxygen consumption were investigated during and immediately after cardiosurgical procedures. There was a significant increase in blood pressure, left ventricular pressure, total systemic resistance, cardiac index, stroke index, peak dp/dt and myocardial oxygen consumption as well as in arterial perfusion pressure during extracorporeal circulation due to i.v.-injection of either one of the drugs. The positive inotropic effects were more pronounced after application of calcium chloride. In emergency situations during anaesthesia or resuscitation, therefore, calcium chloride seems to be of more advantage than calcium gluconate.

摘要

在44例先天性或后天性心脏病、纽约心脏协会(NYHA)心功能分级为II - IV级的患者中,研究了葡萄糖酸钙(10毫升10%)和氯化钙(10毫升5.5%)在心脏外科手术期间及术后即刻对血流动力学、心肌收缩力和心肌氧耗的影响。静脉注射这两种药物中的任何一种后,体外循环期间血压、左心室压力、总体循环阻力、心脏指数、每搏指数、dp/dt峰值和心肌氧耗以及动脉灌注压均显著升高。氯化钙应用后正性肌力作用更为明显。因此,在麻醉或复苏的紧急情况下,氯化钙似乎比葡萄糖酸钙更具优势。

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