Kojimahara M, Ooneda G
Exp Pathol. 1981;19(2):91-9. doi: 10.1016/s0232-1513(81)80039-4.
Proximal segments of the cerebral arteries of aging rats ranging in age from 35 to 45 months were studied electron microscopically. Characteristic features of the medial smooth muscle cells showed single or multiple cytoplasmic focal degradations with electron density, and irregularly shaped and sized cytoplasmic small cave formations (foveations) similar to a spider's web. The latter was a characteristic feature in very old rats. Intercellular spaces were dilated with an increase in amount of basement membrane-like substances, either thick or multilaminated around the bizarrely atrophied smooth muscle cells. Bundles of filaments were present in the basal cytoplasm of the endothelial cells. Bifurcation pads ("Valve-like projections") at the branching points of the cerebral arteries also showed a smooth muscle cell necrosis with deposition of basement membrane-like substances and granulo-vesicular profiles around them, especially in the roots and margins of the bifurcation pads.
对年龄在35至45个月的老龄大鼠脑动脉近端节段进行了电子显微镜研究。内侧平滑肌细胞的特征性表现为单个或多个具有电子密度的细胞质局灶性降解，以及形状和大小不规则的细胞质小凹陷形成（小凹），类似蜘蛛网。后者是非常老龄大鼠的特征性表现。细胞间隙扩张，在异常萎缩的平滑肌细胞周围，基底膜样物质的数量增加，这些物质要么增厚，要么呈多层状。在内皮细胞的基底细胞质中存在成束的细丝。脑动脉分支点处的分叉垫（“瓣膜样突起”）也显示平滑肌细胞坏死，周围有基底膜样物质沉积和颗粒-囊泡样结构，尤其是在分叉垫的根部和边缘。
