Lundsgaard-Hansen P
Dev Biol Stand. 1980;48:287-95.
Whereas European authorities stipulate that a plasmapheresis donor should not give more than about 250 ml of plasma per week, American regulations continue to sanction a weekly "harvesting" volume of 1000 ml. The latter volume equals one third of a donor's plasma volume, and the loss of plasma proteins are identical with those of a patient suffering from a severe nephrotic syndrome. Accordingly, such donors develop hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and abnormal electrophoretic patterns. Recent data give cause for concern with respect to evidence for an increased aggregating tendency of platelets. Pending the clarification of these problems, the necessary quantities of plasma should be procured by increasing the number of donors sufficiently to respect the European volume limitations.
欧洲当局规定，血浆置换捐献者每周捐献的血浆量不应超过约250毫升，而美国的规定仍允许每周“采集”1000毫升。后一量相当于捐献者血浆量的三分之一，血浆蛋白的损失与患有严重肾病综合征的患者相同。因此，这类捐献者会出现低蛋白血症、低白蛋白血症、低丙种球蛋白血症以及异常的电泳图谱。最近的数据令人担忧血小板聚集倾向增加的证据。在这些问题得到澄清之前，应通过充分增加捐献者数量来获取所需的血浆量，以遵守欧洲的量的限制。
