Monk M
Differentiation. 1981;19(2):71-6. doi: 10.1111/j.1432-0436.1981.tb01131.x.
Differentiation in mouse embryo development is represented formally by means of a stem-line model in which: 1. Individual choices are structured so that only a fraction of the cells of a given population receive a signal to undergo a change of state that results in a departure from the stem line. 2. Development proceeds by a series of restrictions in potency of all the cells in the stem line. 3. The stem line harbours the germ cells. 4. The germ cells are returned to a state of totipotency by some event(s) leading to meiosis.
小鼠胚胎发育中的分化通过一种干细胞系模型来形式化表示，其中：1. 个体选择具有特定结构，使得给定群体中只有一部分细胞接收到信号，从而经历状态变化并导致偏离干细胞系。2. 发育通过对干细胞系中所有细胞的潜能进行一系列限制来进行。3. 干细胞系包含生殖细胞。4. 通过一些导致减数分裂的事件，生殖细胞恢复到全能状态。
