小鼠中醛脱氢酶同工酶的遗传学：多个基因座的证据以及Ahd - 2在19号染色体上的定位
Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19.
作者信息
Timms G P, Holmes R S
出版信息
Genetics. 1981 Feb;97(2):327-36. doi: 10.1093/genetics/97.2.327.
Abstract
Electrophoretic and activity variation of the cytoplasmic isozyme of aldehyde dehydrogenase (designated AHD-B4) was observed among inbred strains and Harwell linkage-testing stocks of Mus musculus. The phenotypes are inherited in a normal Mendelian fashion, with two alleles showing co-dominant expression at a single locus (Ahd-2). The locus was shown to segregate independently of Ahd-1 (encoding the mitochondrial AHD-A2 isozymes on chromosome 4; HOLMES 1978). Linkage data of Ahd-2 with ep (pale ears), ru (ruby eyes) and bm (brachymorphic) suggest that it is localized near the centromeric end of chromosome 19. Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented.
摘要
在小家鼠的近交系和哈韦尔连锁测试品系中观察到醛脱氢酶细胞质同工酶（命名为AHD - B4）的电泳和活性变化。这些表型以正常孟德尔方式遗传，两个等位基因在单个位点（Ahd - 2）表现为共显性表达。该位点被证明与Ahd - 1（在4号染色体上编码线粒体AHD - A2同工酶；霍尔姆斯，1978年）独立分离。Ahd - 2与ep（淡耳）、ru（红宝石眼）和bm（短形）的连锁数据表明它位于19号染色体着丝粒末端附近。还提供了第三种AHD同工酶（命名为AHD - Cy）的电泳证据，其主要定位于肝脏微粒体部分。
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引用本文的文献
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Biochem Genet. 1981 Dec;19(11-12):1223-36. doi: 10.1007/BF00484575.
2
Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes.小鼠醛脱氢酶同工酶的生化遗传学：胃和睾丸特异性同工酶的证据。
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本文引用的文献
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