Mitsuyama Y, Tobo M
Folia Psychiatr Neurol Jpn. 1981;35(1):35-42. doi: 10.1111/j.1440-1819.1981.tb00199.x.
A 51-year-old male has suffered the gradual onset of difficulty with memory, concentration and cognition at age 50. He has progressively developed severe dementia accompanied by muscle wasting and fasciculation prominent in the upper arms and shoulders and the bulbar muscles, EMG and muscle biopsy revealed denervation patterns and a CT-scan showed moderate cerebral atrophy. Cases of presenile dementia with motor neuron disease reported in Japan have been reviewed and the possibility of a new clinico-pathologic entity is discussed.
一名51岁男性在50岁时逐渐出现记忆、注意力和认知方面的困难。他逐渐发展为严重痴呆，伴有肌肉萎缩和在上臂、肩部及延髓肌肉明显的肌束震颤，肌电图和肌肉活检显示失神经模式，CT扫描显示中度脑萎缩。本文回顾了日本报道的早老性痴呆合并运动神经元病的病例，并讨论了一种新的临床病理实体的可能性。
