Reichart B, Klinner W, Adam D
Fortschr Med. 1981 Aug 13;99(30):1159-62.
60 minutes after i.v. injection tissue levels of 7 different cephalosporins were obtained using biological assay. The following concentrations were measured: cephalothn 1.4 micrograms/g; cepharin 4.7 micrograms/g; cephacetrile 11.2 micrograms/g; cephradine 15.4 micrograms/g; cefazedone 26.9 micrograms/g; cefamandole 40.3 micrograms/g, and finally cefoxitin 43 micrograms/g. The high tissue levels of cefamandole and cefoxitin are especially remarkable as i.v. doses of both antibiotics had been 50 mg/kg body weight ( doses of all other cephalosporins 100 mg/kg body weight). Except cephalothin, all cephalosporins tested were suitable for antibiotic prophylaxis in cardiac surgery.
静脉注射60分钟后，采用生物测定法测定7种不同头孢菌素的组织水平。测得的浓度如下：头孢噻吩1.4微克/克；头孢匹林4.7微克/克；头孢乙腈11.2微克/克；头孢拉定15.4微克/克；头孢西酮26.9微克/克；头孢孟多40.3微克/克，最后头孢西丁43微克/克。头孢孟多和头孢西丁的组织水平较高尤其显著，因为这两种抗生素的静脉注射剂量均为50毫克/千克体重（所有其他头孢菌素的剂量为100毫克/千克体重）。除头孢噻吩外，所有测试的头孢菌素均适用于心脏手术中的抗生素预防。
