Gersell D J, Katzenstein A L
Hum Pathol. 1981 Jun;12(6):550-61. doi: 10.1016/s0046-8177(81)80069-x.
The clinical and pathologic features in six cases of spindle cell carcinoma of the breast were reviewed. Histologically this tumor is characterized by sheets of spindle cells often containing squamous epithelial islands and numerous cystic spaces lined by epidermoid carcinoma or benign appearing squamous epithelium. Areas of transition from the squamous epithelium or epidermoid carcinoma to malignant spindle cells were seen in all cases. Features of squamous epithelial differentiation were found in the spindle areas of the one tumor examined by electron microscopy. The prognosis in this neoplasm is similar to that in the more common breast carcinomas. Spindle cell carcinoma therefore should be distinguished from fibrosarcoma, stromal sarcoma, and carcinosarcoma. Moreover, it should be separated from the broader category of "metaplastic carcinoma," since this term includes a heterogeneous group of tumors of uncertain histogenesis and prognosis.
回顾了6例乳腺梭形细胞癌的临床和病理特征。组织学上，该肿瘤的特征是成片的梭形细胞，常含有鳞状上皮岛以及许多由表皮样癌或看似良性的鳞状上皮衬里的囊性间隙。所有病例均可见从鳞状上皮或表皮样癌向恶性梭形细胞的过渡区域。在1例经电子显微镜检查的肿瘤的梭形区域发现了鳞状上皮分化的特征。该肿瘤的预后与更常见的乳腺癌相似。因此，梭形细胞癌应与纤维肉瘤、间质肉瘤和癌肉瘤相鉴别。此外，它应与更广泛的“化生癌”类别区分开来，因为这个术语包括一组组织发生和预后不确定的异质性肿瘤。
