Inoue H
Int Orthop. 1981;5(1):47-52. doi: 10.1007/BF00286099.
Specimens obtained from human osteoarthritic knee joints and dog knees with experimentally induced osteoarthritis were used to study the collagenous framework of articular cartilage and subchondral bone in relation to osteoarthritic changes using scanning electron microscopy and light microscopy. Degenerative articular cartilage in osteoarthritic joints showed radial orientation of the collagen fibrils, which were usually discernible as fibrillar bundle formations. Cartilage with extensive lesions often showed cleavages or fissures down to the calcified layer. The cartilagenous collagen fibrils in osteoarthritic specimens merged into the subchondral bone plate making the tidemark and the osteochondral junction irregular or obscure. The trabecular orientation of subchondral bone changed with alteration in the articular cartilage and with reactive changes in the subchondral bone, showing the effect of cartilaginous degeneration on its ultrastructure.
取自人类骨关节炎膝关节和实验性诱导骨关节炎的犬膝关节的标本，通过扫描电子显微镜和光学显微镜，用于研究关节软骨和软骨下骨的胶原框架与骨关节炎变化的关系。骨关节炎关节中的退行性关节软骨显示胶原纤维呈放射状排列，通常可辨别为纤维束形成。有广泛病变的软骨常出现直至钙化层的劈裂或裂隙。骨关节炎标本中的软骨胶原纤维融入软骨下骨板，使潮标和骨软骨交界处不规则或模糊不清。软骨下骨的小梁方向随关节软骨的改变和软骨下骨的反应性变化而改变，显示软骨退变对其超微结构的影响。
