Fang S M, Janes J O, Nelson J A, Liou I F
Invest Radiol. 1981 Jul-Aug;16(4):330-6. doi: 10.1097/00004424-198107000-00016.
The kinetics of iopanoate metabolism have been examined using a physiologic and pharmacokinetic model in rats. The kinetics of iopanoic acid concentration in blood and in eight other major tissue distribution compartments have been determined and fitted to computer-generated concentrations based on a well-established pharmacokinetic model. The results of these studies in nonfasted, conscious rats revealed that after gastric administration of the contrast material tissue concentrations never exceed 30 microgram/g even in the liver. In addition, a clear-cut enterohepatic circulation of the drug was noted in the experimental setting and had to be incorporated into a computer-generated model to account for differences in the predicted model as compared to the experimental data. Such data point out the importance of knowledge of pharmacokinetics of a drug for development of more appropriate dosage regimens of older compounds, theoretical design and testing of new compounds, or to explain clinically observed drug-related phenomenon.
已使用生理和药代动力学模型在大鼠中研究了碘番酸代谢的动力学。已确定血液和其他八个主要组织分布隔室中碘番酸浓度的动力学，并根据成熟的药代动力学模型将其拟合为计算机生成的浓度。这些在非禁食、清醒大鼠中的研究结果表明，在胃内给予造影剂后，即使在肝脏中，组织浓度也从未超过30微克/克。此外，在实验环境中观察到该药物有明显的肝肠循环，并且必须将其纳入计算机生成的模型中，以解释预测模型与实验数据之间的差异。这些数据指出了了解药物药代动力学对于制定更合适的老化合物给药方案、新化合物的理论设计和测试或解释临床观察到的药物相关现象的重要性。
