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乳鼠脂肪消化、吸收及转运的研究。I. 脂肪酸组成及主要脂质成分的浓度。

Studies on fat digestion, absorption, and transport in the suckling rat. I. Fatty acid composition and concentrations of major lipid components.

作者信息

Fernando-Warnakulasuriya G J, Staggers J E, Frost S C, Wells M A

出版信息

J Lipid Res. 1981 May;22(4):668-74.

PMID:7276740
Abstract

The lipids of rat milk, the contents of 9-- 10-day-old rat stomach and intestine, lymph, plasma, and liver were quantitated and their fatty acids were analyzed. Rat milk consists of 97% triacylglycerols, of which 35% of the fatty acids are of medium chain length (C8-C12). However, stomach triacylglycerols show a 25% reduction in medium chain fatty acids, which indicates preferential hydrolysis of medium chain fatty acids in the stomach. The intestinal lumen free fatty acid composition shows decreased medium chain fatty acids compared to long chain fatty acids, indicating preferential absorption of the former. Lymph was shown to contain a significant amount (approximately 22%) of medium chain fatty acids. The decreased content of medium chain fatty acids in vena cava blood compared to portal blood, and also the lower concentration of medium chain fatty acids in liver compared to blood, indicates preferential use of these fatty acids by the liver.

摘要

对9至10日龄大鼠的乳汁、胃和肠道内容物、淋巴、血浆及肝脏中的脂质进行了定量分析,并对其脂肪酸进行了分析。大鼠乳汁中97%为三酰甘油,其中35%的脂肪酸为中链长度(C8 - C12)。然而,胃中的三酰甘油显示中链脂肪酸减少了25%,这表明胃中中链脂肪酸发生了优先水解。与长链脂肪酸相比,肠腔游离脂肪酸组成显示中链脂肪酸减少,表明前者优先被吸收。研究表明,淋巴中含有大量(约22%)的中链脂肪酸。与门静脉血相比,腔静脉血中中链脂肪酸含量降低,且与血液相比肝脏中中链脂肪酸浓度较低,这表明肝脏优先利用这些脂肪酸。

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