Nakano M, Nakamura Y, Juni K, Tomitsuka T
J Pharmacobiodyn. 1980 Dec;3(12):702-8. doi: 10.1248/bpb1978.3.702.
Dry agar beads containing theophylline were prepared. The release rate of theophylline from the agar beads in vitro was smaller than the dissolution rate of the drug from pure drug powders. The salivary levels of the drug following oral administration of the agar beads to three healthy volunteers were determined by reversed-phase high pressure liquid chromatography. Results of pharmacokinetic analyses indicated sustained absorption of the drug following the administration of the agar beads.
制备了含有茶碱的干燥琼脂珠。茶碱从琼脂珠中的体外释放速率小于其从纯药物粉末中的溶解速率。通过反相高效液相色谱法测定了三名健康志愿者口服琼脂珠后药物的唾液水平。药代动力学分析结果表明，服用琼脂珠后药物吸收持续。
