Stec G P, Atkinson A J
J Pharmacokinet Biopharm. 1981 Apr;9(2):167-80. doi: 10.1007/BF01068080.
Recent pharmacokinetic studies indicate that both flow and permeability contribute to intercompartmental clearance. A previous analysis of flow and permeability components of transcapillary exchange has been adapted to a three-compartment model of PA and NAPA pharmacokinetics. Data from a study that simultaneously determined the pharmacokinetic parameters of these two compounds made it possible to estimate permeability coefficients for the fast equilibrating compartment averaging 3.32 liters/min for PA and 1.35 liters/min for NAPA, and for the slow equilibrating compartment averaging 2.05 liters/min for PA and 0.78 liters/min for NAPA. These results were then used to estimated flow-intercompartmental clearance relationships for PA and NAPA and to predict the extent of hemodynamic changes causing the slow intercompartmental clearance of NAPA to decrease by 77% during hemodialysis without an apparent alteration in fast intercompartmental clearance.
最近的药代动力学研究表明，血流量和通透性均对隔室间清除率有影响。先前对跨毛细血管交换的血流量和通透性成分的分析已应用于对氨基马尿酸（PA）和N-乙酰对氨基马尿酸（NAPA）药代动力学的三室模型。一项同时测定这两种化合物药代动力学参数的研究数据，使得能够估算快速平衡室的通透性系数，PA平均为3.32升/分钟，NAPA平均为1.35升/分钟；以及慢速平衡室的通透性系数，PA平均为2.05升/分钟，NAPA平均为0.78升/分钟。这些结果随后被用于估算PA和NAPA的血流量-隔室间清除率关系，并预测导致NAPA在血液透析期间慢速隔室间清除率降低77%而快速隔室间清除率无明显改变的血流动力学变化程度。
