Amano K, Tanikawa T, Iseki H, Kawabatake H, Notani M, Kawamura H, Kitamura K
Appl Neurophysiol. 1978;41(1-4):66-78. doi: 10.1159/000102402.
Rostral mesencephalic reticulotomy (RMR) has been performed since 1973 for relief of intractable pain. The target area is in the midbrain reticular formation (MRF) bordering the periaqueductal gray matter at the superior collicular level. The target of RMR is 13--16 mm posterior to the midpoint of the AC-PC line and 5--8 mm below the AC-PC line. The laterality of the target is measured from the center of the aqueduct, ranging 5 to 8 mm from the midline. The rationale for this procedure is based upon the previous findings that the brain stem reticular formation plays a more important role above the spinal cord level than the lateral spinothalamic tract in the central conduction of nociceptive impulse. In the present study, intraoperative single neuron recording was made with tungsten microelectrodes from the human midbrain tegmentum in response to peripheral pinprick stimulation. These nociceptive neurons were classified into three groups in regard to the unit latency from the peripheral pinprick stimulation.
自1973年以来，一直采用延髓中脑网状结构切开术（RMR）来缓解顽固性疼痛。目标区域位于中脑网状结构（MRF），在中脑上丘水平与导水管周围灰质相邻。RMR的靶点位于AC-PC线中点后方13 - 16毫米处，且在AC-PC线下方5 - 8毫米处。靶点的侧方位置是从导水管中心开始测量，距中线5至8毫米。该手术的理论依据基于先前的研究结果，即在伤害性冲动的中枢传导中，脑干网状结构在脊髓水平以上比脊髓丘脑侧束发挥更重要的作用。在本研究中，术中使用钨微电极从人类中脑被盖记录对周围针刺刺激产生反应的单个神经元。根据外周针刺刺激后的单位潜伏期，将这些伤害性神经元分为三组。
