Zarchin N, Mayevsky A
Mech Ageing Dev. 1981 Jul;16(3):285-94. doi: 10.1016/0047-6374(81)90104-4.
The effects of age on the responses of the brain to decapitation (complete ischemia) were tested in the awake and anesthetized rat. The metabolic and reflected light activities were evaluated by the use of a DC fluorometer/reflectometer (one or two hemispheres) and the electrical activity was measured by electrocorticogram. In all 81 animals used in these experiments the above-mentioned parameters were measured, to enable comparison between the age groups. The rats were divided into six age groups ranging from 2 to 120 weeks and each age group was subdivided into awake and anesthetized animals. The results can be summarized as follows. (1) The rate of energy consumption was lower in the young (2 weeks) and the old rats (120 weeks) compared to the adult rats. (2) The effect of anesthetic was more pronounced in the young and the old rats than in the adult rats. (3) The electrical activity was in good correlation with the energy availability in all animals of various ages as well as in the awake and anesthetized rats.
在清醒和麻醉的大鼠身上测试了年龄对大脑断头（完全缺血）反应的影响。通过使用直流荧光计/反射计（一个或两个半球）评估代谢和反射光活动，并通过脑电图测量电活动。在这些实验中使用的所有81只动物都测量了上述参数，以便在不同年龄组之间进行比较。大鼠被分为六个年龄组，范围从2周到120周，每个年龄组又细分为清醒和麻醉的动物。结果可总结如下：（1）与成年大鼠相比，幼鼠（2周）和老年大鼠（120周）的能量消耗率较低。（2）麻醉对幼鼠和老年大鼠的影响比对成年大鼠更明显。（3）在不同年龄的所有动物以及清醒和麻醉的大鼠中，电活动与能量供应密切相关。
