Richardson J, Keeling M
Med Hypotheses. 1981 Jun;7(6):765-80. doi: 10.1016/0306-9877(81)90087-6.
The effects of stress on the central nervous system, endocrine balance and immunity were observed in male Sprague-Dawley rats. Food and water were supplied in unlimited quantities. Extraneous odors were kept away from the control room by an exhaust fan in the adjacent room. At 70 days, experimentation occured for 20 days. In the aspirin, parathroid, serotonin, and pineal groups, there was no significant difference between the undistrubed control and experimental groups. A significant reduction in both the pituitary and adrenal weights was seen in the melatonin experimental group and the undisturbed control group. The placebo control group showed a significant increase in both the pituitary and adrenal gland weights. Stress was blocked in the groups receiving aspirin, parathroid, serotonin, and pineal preparations. The melatonin group, however, very significantly blocked the stress in that both the pituitary and adrenal weights were significantly below the undisturbed control group. The aspirin blocked stress by inhibiting synthesis of prostaglandins. Melatonin works through the pituitary-adrenal axis to reduce adrenal secretion.
在雄性斯普拉格-道利大鼠身上观察了应激对中枢神经系统、内分泌平衡和免疫的影响。不限量供应食物和水。通过相邻房间的排气扇使控制室内远离外来气味。在70天时，进行了20天的实验。在阿司匹林、甲状旁腺、血清素和松果体组中，未受干扰的对照组与实验组之间没有显著差异。褪黑素实验组和未受干扰的对照组的垂体和肾上腺重量均显著降低。安慰剂对照组的垂体和肾上腺重量均显著增加。在接受阿司匹林、甲状旁腺、血清素和松果体制剂的组中，应激被阻断。然而，褪黑素组非常显著地阻断了应激，因为垂体和肾上腺重量均显著低于未受干扰的对照组。阿司匹林通过抑制前列腺素的合成来阻断应激。褪黑素通过垂体-肾上腺轴发挥作用以减少肾上腺分泌。
