Halmi K A, Dekirmenjian H, Davis J M, Casper R, Goldberg S
Arch Gen Psychiatry. 1978 Apr;35(4):458-60. doi: 10.1001/archpsyc.1978.01770280068007.
Urinary catecholamine levels were measured in 25 anorexia nervosa patients at the time when they were acutely ill with secondary depressive symptoms and again after treatment and weight gain to see whether changes in weight, activity levels, and symptoms of depression occurring during treatment might be associated with changes in urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations. The latter was significantly lower in the acutely ill anorectics than in the control group. An increase in urinary MHPG concentration after treatment was significantly correlated with a decrease in depressive symptomatology. The increase in urinary MHPG level during treatment did not correlate significantly with change in patient's activity level. There seems to be a relationship between MHPG and the symptom of depression in a group of patients who do not carry a primary diagnosis of depression.
对25名神经性厌食症患者在急性发病伴有继发性抑郁症状时以及治疗后体重增加时的尿儿茶酚胺水平进行了测量，以观察治疗期间体重、活动水平和抑郁症状的变化是否可能与尿3-甲氧基-4-羟基苯乙二醇（MHPG）浓度的变化相关。急性发病的厌食症患者的尿MHPG水平显著低于对照组。治疗后尿MHPG浓度的增加与抑郁症状的减轻显著相关。治疗期间尿MHPG水平的增加与患者活动水平的变化无显著相关性。在一组未患有原发性抑郁症的患者中，似乎MHPG与抑郁症状之间存在关联。
