巴仙吉犬与灵缇犬杂交犬：抗原诱导的肺容积变化。

The Basenji-Greyhound dog: antigen-induced changes in lung volumes.

作者信息

Hirshman C A, Leon D A, Bergman N A

出版信息

Respir Physiol. 1981 Mar;43(3):377-88. doi: 10.1016/0034-5687(81)90117-1.

Abstract

Subdivisions of lung volume, closing volume (CV), pulmonary resistance (RL) and dynamic pulmonary compliance (Cdyn) were measured before and after bronchial challenge with Ascaris suum in seven ascaris-sensitive Basenji-Greyhound (BG) crossbreed dogs. RL increased from a control value of 1.41 +/- 0.43 (mean +/- SE) cm H2O/L/sec to 21.4 +/- 5.15 (P Less Than 0.01) and Cdyn decreased from 163 +/- 32 ml/cm H2O to 43 +/- 11 (P Less Than 0.01) in the first 15 min following ascaris-antigen aerosol (AAA) challenge. Vital capacity (VC) decreased from 1581 +/- 147 ml to 944 +/- 86 (P Less Than 0.005) ml and residual volume (RV) increased from 381 +/- 63 to 577 +/- 68 ml (P Less Than 0.005) following AAA challenge. We conclude that the pulmonary mechanical changes in the BG dog following antigen challenge more closely resemble the changes observed in acute human asthma than do changes occurring in the mongrel dog.

摘要

在七只对蛔虫敏感的巴仙吉犬与灵缇犬的杂交犬（BG杂交犬）中，测量了猪蛔虫支气管激发前后的肺容积细分、闭合容积（CV）、肺阻力（RL）和动态肺顺应性（Cdyn）。在猪蛔虫抗原气雾剂（AAA）激发后的前15分钟内，RL从对照值1.41±0.43（平均值±标准误）厘米水柱/升/秒增加到21.4±5.15（P＜0.01），Cdyn从163±32毫升/厘米水柱降低到43±11（P＜0.01）。AAA激发后，肺活量（VC）从1581±147毫升降低到944±86（P＜0.005）毫升，残气量（RV）从381±63增加到577±68毫升（P＜0.005）。我们得出结论，与杂种犬相比，BG犬抗原激发后的肺力学变化更类似于急性人类哮喘中观察到的变化。