Schmidt P M
Schweiz Med Wochenschr. 1981 Aug 15;111(33):1201-7.
When hemolytic anemia is diagnosed the etiology of most cases can be determined by simple methods: familial and personal history, physical examination and search for erythrocyte morphologic anomalies (spontaneous or induced). These latter are often typical of a particular mechanism of hemolysis. The antihuman globulin test and the screening test for G-6-PD deficiency and sickle cell anemia are included in the routine tests. More specialized tests should be performed only in doubtful cases. For example, the determination of erythrocyte survival by an isotopic method may confirm suspected mild hemolysis. Measurement of several enzyme activities may detect an enzymatic deficiency. Hemoglobin electrophoresis may reveal hemoglobinopathy.
当诊断出溶血性贫血时，大多数病例的病因可通过简单方法确定：家族史和个人史、体格检查以及寻找红细胞形态异常（自发或诱导的）。后者通常是特定溶血机制的典型表现。常规检查包括抗人球蛋白试验以及G-6-PD缺乏症和镰状细胞贫血的筛查试验。仅在可疑病例中才应进行更专业的检查。例如，通过同位素方法测定红细胞存活率可证实疑似的轻度溶血。测量几种酶活性可能检测到酶缺乏症。血红蛋白电泳可能揭示血红蛋白病。
