苯妥英钠与地塞米松的相互作用：一项此前未报道的观察结果。

Phenytoin-dexamethasone interaction: a previously unreported observation.

作者信息

Lawson L A, Blouin R A, Smith R B, Rapp R P, Young A B

出版信息

Surg Neurol. 1981 Jul;16(1):23-4. doi: 10.1016/s0090-3019(81)80054-7.

Abstract

A possible drug interaction between phenytoin and dexamethasone was evaluated by comparing serum phenytoin concentrations in 23 patients receiving both drugs with those of a control group of 15 patients receiving phenytoin only. Serum phenytoin concentrations obtained 24 hours after a loading dose of 11 mg per kilogram body weight administered intravenously and 13 mg/kg given intramuscularly were examined. The total amounts of dexamethasone administered during the 24-hour period ranged from 16 to 150 mg. The average serum phenytoin concentration was 17.28 +/- 3.49 micrograms/ml in patients receiving both drugs, as compared to 12.48 +/- 3.52 micrograms/ml in patients receiving only phenytoin (p less than 0.001). Our results suggest that serum phenytoin concentrations should be monitored in patients receiving concurrent dexamethasone therapy.

摘要

通过比较23例同时接受苯妥英钠和地塞米松治疗的患者与15例仅接受苯妥英钠治疗的对照组患者的血清苯妥英钠浓度，评估了苯妥英钠与地塞米松之间可能存在的药物相互作用。对静脉注射每千克体重11毫克负荷剂量以及肌肉注射每千克体重13毫克后24小时测得的血清苯妥英钠浓度进行了检查。在24小时期间给予的地塞米松总量为16至150毫克。同时接受两种药物治疗的患者血清苯妥英钠平均浓度为17.28±3.49微克/毫升，而仅接受苯妥英钠治疗的患者为12.48±3.52微克/毫升（p<0.001）。我们的结果表明，接受地塞米松联合治疗的患者应监测血清苯妥英钠浓度。