Kasantikul V, Brown W J
Surg Neurol. 1981 Jul;16(1):30-5. doi: 10.1016/s0090-3019(81)80059-6.
The microvasculature of normal acoustic nerve tissue and small intracanalicular and large extracanalicular neurilemmomas was analyzed by electron microscopy. The capillaries of normal acoustic nerve were nonfenestrated, but the microvasculature in nerve-sheath neoplasms was fenestrated. Hypertrophy and hyperplasia of endothelial cells were observed only in the small lesions. The proliferated and enlarge endothelial cells often partially occluded the vascular lumen and formed multichannel vascular lumina. Many fenestrae of capillaries were found in small neoplasms, but these were rarely identified in the large extracanalicular lesions. The gap junctions of endothelium in small nerve-sheath neoplasms were long, wavy, and convoluted, had no openings, and differed from those of large lesions in which the tight junctions were short, straight, and occasionally patent. Additionally, heavy vascularization and erythrocytes within basement membranes were observed only in large neurilemmomas. These ultrastructural features may constitute a basis for differences between large and small acoustic neurilemmomas noted in cerebrospinal fluid findings.
通过电子显微镜分析正常听神经组织、小的内耳道内和大的外耳道内神经鞘瘤的微血管系统。正常听神经的毛细血管无窗孔，但神经鞘瘤中的微血管系统有窗孔。仅在小病变中观察到内皮细胞肥大和增生。增殖并增大的内皮细胞常部分阻塞血管腔并形成多通道血管腔。在小肿瘤中发现许多毛细血管窗孔，但在大的外耳道外病变中很少见到。小神经鞘瘤中内皮细胞的缝隙连接长、呈波浪状且盘绕，无开口，与大病变的不同，大病变中的紧密连接短、直且偶尔开放。此外，仅在大神经鞘瘤中观察到基底膜内的重度血管化和红细胞。这些超微结构特征可能构成脑脊液检查结果中所见大小听神经鞘瘤差异的基础。
