单纯放疗与采用阿霉素和5-氟尿嘧啶化疗联合放疗治疗支气管癌的比较。
Comparison of radiotherapy alone and radiotherapy with chemotherapy using adriamycin and 5-fluorouracil in bronchogenic carcinoma.
作者信息
Anderson G, Deeley T J, Smith C, Jani J
出版信息
Thorax. 1981 Mar;36(3):190-3. doi: 10.1136/thx.36.3.190.
Abstract
Eighty-two patients with histologically confirmed lung cancer were randomly allocated to receive either radiotherapy alone (2400-3200 rads, depending upon cell type) or the same dose of radiotherapy followed by four cycles of adriamycin and 5-fluorouracil. Eighty-one patients were evaluated and for the group as a whole survival was better in the undifferentiated group assigned to receive adjuvant chemotherapy but survival in the patients with squamous tumours was not significantly prolonged. The chemotherapy was not unduly toxic.
摘要
82例经组织学确诊的肺癌患者被随机分配，一组单纯接受放疗（根据细胞类型给予2400 - 3200拉德的剂量），另一组接受相同剂量的放疗后再进行四个周期的阿霉素和5-氟尿嘧啶联合化疗。对81例患者进行了评估，结果显示，接受辅助化疗的未分化癌组总体生存率更高，但鳞状肿瘤患者的生存期并未显著延长。化疗的毒性并不严重。
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